|
Symbol Name ID |
Lmnb2
lamin B2 MGI:96796 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Microcephaly |
Frequent falls |
Ventriculomegaly |
Pachygyria |
Simplified gyral pattern |
Hypoplasia of the frontal lobes |
Agenesis of corpus callosum |
Interhemispheric cyst |
Gray matter heterotopia |
Gait ataxia |
Myoclonus |
Action myoclonus |
Intellectual disability, severe |
Hyperreflexia |
Global developmental delay |
Bilateral tonic-clonic seizure |
Generalized myoclonic seizure |
Status epilepticus |
| Disease(s) Associated with LMNB2 | ||||||||||||||||||
| primary autosomal recessive microcephaly | ||||||||||||||||||
| progressive myoclonus epilepsy 9 |
| Mouse Phenotypes | nervous system phenotype |
abnormal neuronal migration |
abnormal neuronal precursor proliferation |
abnormal cortical plate morphology |
absent cerebellar foliation |
thin external granule cell layer |
decreased brain size |
abnormal forebrain morphology |
abnormal hippocampus layer morphology |
abnormal cerebral cortex morphology |
abnormal stratification in cerebral cortex |
abnormal cerebellum morphology |
absent Purkinje cell layer |
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| Availability | Mouse Genotype | |||||||||||||
| Lmnb2tm1Ccof/Lmnb2tm1Ccof | ||||||||||||||
| Lmnb2tm1Yxz/Lmnb2tm1Yxz | ||||||||||||||
| Lmnb2tm2Sgy/Lmnb2tm2Sgy | * | |||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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